You can profit when a liquidity event occurs. This means the company has been acquired or the company lists with public markets via IPO. Or, if you sell your shares on the secondary market for a profit.
There are no fees for investors. Issuance makes money from their technology as well as service fees for each fundraise.
Investing in start-ups is risky and you should not make an investment in start-ups that you can't afford to lose.